Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury
نویسندگان
چکیده
Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one major consequences TBI, targeting p-tau TBI may lead to development new therapy. Twenty-five pigs underwent a controlled cortical impact. One hour after were administered either vehicle (n = 13) or PNT001 12), monoclonal antibody for cis conformer phosphorylated at threonine 231. Plasma biomarkers neural assessed 14 days. Diffusion tensor imaging was performed day 1 and injury, these compared historical control animals 4). The fractional anisotropy data showed significant white matter groups corona radiata. At days, vehicle-treated pigs, but not PNT001-treated animals, exhibited sham ipsilateral had significantly lower levels plasma glial fibrillary acidic protein (GFAP) 2 4. These findings demonstrate subtle reduction areas neurological treatment with following TBI. support additional studies as well potential use this agent clinical trials near future.
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2023
ISSN: ['2227-9059']
DOI: https://doi.org/10.3390/biomedicines11071807